杜武勋教授认为“整体观念”“辩证论治”是中医理论特色,临床只有“病证结合”“方证相应”“药证相符”“用量恰当”“药时到位”,才能体现出中医学复方整体疗效。此为指导,结合现代科学技术,形成稳定的“病证结合,方、证、量、时、效的系统-系统整体动态循证研究模式”。综合运用生物色谱技术、系统生物学、网络药理学、药代-药效动力学等方法,开展中医心病证候规范、复方中药药效物质基础及作用机制研究,取得了多项国家及天津市自然科学基金项目,发表论文百余篇,代表性论文如下:
[1] Liu ZC, Fu HJ, Li NC, Deng FJ, Gan YK, Ye YJ, Huang BH, Liu C, Chen JH, Li XF. Systematic pharmacology and experimental validation to elucidate the inflammation-associated mechanism of Huanglian Wendan (HLWD) decoction in the treatment of MAFLD associated with atherosclerosis. J Ethnopharmacol. 2024 Sep 18;337(Pt 1):118841. doi: 10.1016/j.jep.2024.118841. Epub ahead of print. PMID: 39299361.(IF: 4.360)
[2] Chen J, Liu Z, Deng F, Liang J, Fan B, Zhen X, Tao R, Sun L, Zhang S, Cong Z, Li X, Du W. Mechanisms of Lian-Gui-Ning-Xin-Tang in the treatment of arrhythmia: Integrated pharmacology and in vivo pharmacological assessment. Phytomedicine. 2022 Feb 12;99:153989. doi: 10.1016/j.phymed.2022.153989. Epub ahead of print. PMID: 35272242.(IF: 5.340
[3] Deng F, Li X, Tang C, Chen J, Fan B, Liang J, Zhen X, Tao R, Zhang S, Cong Z, Du W, Zhao H, Xu L. Mechanisms of Xiong-Pi-Fang in treating coronary heart disease associated with depression: A systematic pharmacology strategy and in vivo pharmacological validation. J Ethnopharmacol. 2022 Aug 18;298:115631. doi: 10.1016/j.jep.2022.115631. Epub ahead of print. PMID: 35987411.(IF: 4.360
[4] Li X, Tian G, Xu L, Sun L, Tao R, Zhang S, Cong Z, Deng F, Chen J, Yu Y, Du W, Zhao H. Wenxin Keli for the Treatment of Arrhythmia-Systems Pharmacology and In Vivo Pharmacological Assessment. Front Pharmacol. 2021 Aug 26;12:704622. doi: 10.3389/fphar.2021.704622. PMID: 34512338; PMCID: PMC8426352.(IF: 5.811)
[5] Jiayu L, Xiaofeng L, Jinhong C, Fangjun D, Boya F, Xin Z, Zidong C, Rui T, Lu Y, Shule Q, Runying W, Wuxun D. Study on the mechanisms and Pharmacodynamic substances of Lian-Gui-Ning-Xin-Tang on Arrhythmia Therapy based on Pharmacodynamic-Pharmacokinetic associations. Heliyon. 2024 Aug 14;10(16):e36104. doi: 10.1016/j.heliyon.2024.e36104. PMID: 39253118; PMCID: PMC11381611
[6] Zhang L, Zhang Y, Zhu M, Pei L, Deng F, Chen J, Zhang S, Cong Z, Du W, Xiao X. An Integrative Pharmacology-Based Strategy to Uncover the Mechanism of Xiong-Pi-Fang in Treating Coronary Heart Disease with Depression. Front Pharmacol. 2021 Apr 1;12:590602. doi: 10.3389/fphar.2021.590602. PMID: 33867976; PMCID: PMC8048422
[7] Zhao L, Guo R, Cao N, Lin Y, Yang W, Pei S, Ma X, Zhang Y, Li Y, Song Z, Du W, Xiao X, Liu C. An Integrative Pharmacology-Based Pattern to Uncover the Pharmacological Mechanism of Ginsenoside H Dripping Pills in the Treatment of Depression. Front Pharmacol. 2021 Feb 15;11:590457. doi: 10.3389/fphar.2020.590457. PMID: 33658934; PMCID: PMC7917282
[8] Zhang F, Qiao X, Lu H, Zhang S, Du W, Xiao X. Application of a sensitive and specific LC-ESI-MS/MS method for the simultaneous quantification of twelve bioactive components in dog plasma for an intravenous pharmacokinetic study of Yiqifumai Injection in beagle dogs. Biomed Chromatogr. 2018 Aug;32(8):e4256. doi: 10.1002/bmc.4256. Epub 2018 May 16. PMID: 29644721
[9] Fugeng Zhang , Yu Zhang , Xiaofeng Li , Shaoqiang Zhang ,Mingdan Zhu , Wuxun Du* , Xuefeng Xiao*.Research on Q-markers of Qiliqiangxin capsule for chronic heart failure treatment based on pharmacokinetics and pharmacodynamics association,Phytomedicine,2018,doi:10.1016/j.phymed.2018.03.003.
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